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Physiological Proteomics (3 credits)
PNB 5396-020
Instructor(s): Schwartz
Current experimental and computational techniques available to study the proteome and its role in cellular and organismal physiology.
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Honors Core: Computational Molecular Biology (3 credits)
MCB/CSE/BME/PNB 1401
Instructor(s): Mandoiu, Nelson, Schwartz
Introduction to research in computational biology through lectures, computer lab exercises, and mentored research projects. Topics include gene and genome structure, gene regulation, mechanisms of inheritance, biological databases, sequence alignment, motif finding, human genetics, forensic genetics, stem cell development, comparative genomics, early evolution, and modeling complex systems. CA 3.
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Molecular and Cellular Neurobiology (3 credits)
PNB 6426
Instructor(s): deBlas, Walikonis, Schwartz
Molecular and cellular aspects of modern neurobiology including the analysis of neuronal proteins and their post-translational modifications, the dynamics of cellular substructures, and various signaling mechanisms in nerve cells including synaptic transmission. Molecular and cellular biology of selected neurological disorders.
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The Proteomics of Post-Translational Modifications (1 credit)
PNB 6400
Instructor(s): Schwartz
This one-credit graduate seminar will provide a survey of protein post-translational modifications (e.g., phosphorylation, glycosylation, sumoylation, acetylation, etc.), and the various proteomic methodologies used to discover their existence.
Lab News
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Aug 23 2017
Dan officially becomes an Associate Professor (with tenure). -
Aug 09 2017
Josh is co-first author on "An in silico analysis of primary and secondary structure specificity determinants for human peptidylarginine deiminase types 2 and 4." [ link ] -
May 09 2017
Josh successfully defends his doctoral thesis titled "Using Bacteria to Characterize and Engineer Protein Kinase Substrate Specificity". Congratulations Dr. Lubner! [ file ] -
May 07 2017
Jen graduates as a honors student double major in Biological Sciences and German. Jen will be a Immunology graduate student at the University of Chicago in the fall. Congrats Jen! -
May 06 2017
Amanda graduates with her MS degree and will be attending SUNY Downstate as a medical student in the fall. Congrats Amanda! -
Apr 20 2017
Amanda successfully defends her Master's Thesis titled "Toward the Characterization of Mammalian Sterile20-like Kinase 3 (MST3) and the Conserved Herpesviridae Protein Kinases (CHPKs) through Phosphorylation Motifs". [ file ] -
Mar 27 2017
Dan is a guest speaker at the University of Vermont Biology Department seminar series. -
Mar 15 2017
Dan gives a keynote address at the UCH Molecular Biology & Biophysics departmental retreat. -
Jan 18 2017
New publication: Cushing's Syndrome mutant PKAL205R exhibits altered substrate specificity. [ link ] -
Jan 17 2017
Josh is selected to give a short talk at the 2017 Keystone Symposium on Kinases (March 5-9, Breckenridge, CO). His talk will be titled "Using Bacteria to Characterize and Engineer Protein Kinase Specificity". [ link ] -
Dec 05 2016
The Schwartz Lab submits two new preprints to biorXiv. [ link | link ] -
Nov 15 2016
Josh is selected as a Keystone Symposia Future of Science Fund Scholarship Recipient for the 2017 Keystone Kinase conference. Congrats Josh! [ link ] -
Sep 23 2016
Dan sits on an "academic job search" faculty panel at the Alumni House as part of National Post-Doc Appreciation Week. [ link ] -
Sep 19 2016
The Schwartz Lab is awarded an R21 grant from NIH/NINDS titled "Determining the Substrate Specificity of Wild-Type and Encephalopathy-Associated Mutants of Protein Kinase CDKL5". [ link ] -
Jul 22 2016
Danielle Caefer (BME '19) joins the wet lab as an honors student researcher. Welcome Danielle! -
Jul 11 2016
Brandon Cheng (Eng '19) officially joins the Schwartz Lab on the dry lab side. Welcome Brandon! -
Jul 01 2016
The Biotechnology-Bioservices Center officially transitions to become the Center for Open Research Resources and Equipment (Dan remains as Director of the new Center). [ link ] -
May 08 2016
Prakhar and Amanda both get their Bachelor's degrees. Congrats! Prakhar will be wrapping up his Master's degree in the coming months and will be starting as a Med Student at UCH in the fall. Amanda is now officially a Master's student in the lab. -
Apr 29 2016
Josh is the recipient of the 2016 James S. Romanow memorial award, not only for his excellent research, but also for his service to his peers. Well deserved Josh. [ link ] -
Mar 19 2016
Josh presented a short talk titled "Reprogramming protein kinase substrate specificity through synthetic and disease-associated mutations" at the 39th East Coast Nerve Net (ECNN) at Woods Hole, MA. [ file ] -
Mar 16 2016
Jen was accepted into (and will be attending!) the Summer Student Program at The Jackson Laboratory in Bar Harbor, ME. -
Oct 22 2015
Dan was a panelist on the "Academic Job Search" event through the Grad School. -
Jul 15 2015
Sean gives a seminar titled "Improving proteomic technologies using motifs" at the STEM seminar series. [ link ] -
Jul 08 2015
Dan is appointed Director of the Biotechnology Bioservices Center (BBC). [ link ] -
May 22 2015
New publication: "An autophosphorylation site database for leucine-rich repeat receptor-like kinases in Arabidopsis thaliana". [ link ] -
May 09 2015
Joey, Jerlon, Julie, Jesse, Will, and Andrew all graduate (that leaves only Josh, Jordan, and Jen with "J" names in the lab). Congrats! We're certain that they will all go on to do great things - please keep in touch. -
May 06 2015
Provost Academic Plan proposal to create a proteomics core facility on the Storrs campus is selected for funding! [ link ] -
May 04 2015
Jesse makes the decision to attend University of Rochester's MD/PhD program in the fall. Congrats Jesse! -
Apr 10 2015
Julie and Jesse present their research in the lab at the 18th Annual Frontiers poster exhibition. Andrew and Dillon also present on their research outside our lab. [ file ] -
Mar 25 2015
Dan presents a seminar in the Chemistry department titled "Discovering and engineering protein kinase specificity". -
Mar 23 2015
Julie makes the decision to attend Brandeis University for her Ph.D. starting in the fall. Congrats Julie! -
Feb 05 2015
Jen Allocco (Biological Sciences and German '17) starts working in the wet lab as a student researcher. -
Jan 20 2015
Dan is co-instructing "PNB 6426: Molecular and Cellular Neurobiology" with Drs. de Blas and Walikonis. -
Jan 19 2015
Amanda Wildstein (Biological Sciences, '16) joins the wet lab as an honors student researcher. Welcome Amanda! -
Jan 11 2015
Dan and Josh present a poster at the "Biological Code of Cell Signaling" Keystone Conference in Steamboat Springs, CO. -
Nov 19 2014
Dan gives a STEM seminar sponsored by the McNair Scholars Program and the Office of Undergraduate Research. -
Nov 17 2014
Prakhar Bansal (MCB '16) starts working in the lab as a front-end developer. Welcome Prakhar! -
Oct 21 2014
Dan is a panelist on the "Rewards and Challenges of Entrepreneurship" panel sponsored by OVPR and CCEI. -
Sep 19 2014
Dan gives a seminar in the Department of Animal Science. -
Sep 17 2014
Dan sits on a faculty panel for post-doc appreciation week. -
Aug 19 2014
Dan is instructing PNB 6400. The topic this semester is "The proteomics of post-translational modifications". -
Aug 19 2014
Andrew Lawson (CSE '15 and University Scholar) joins the dry lab as a programmer. Welcome Andrew! -
Aug 04 2014
Dillon Jones (CSE '15) joins the dry lab as a programmer. Welcome Dillon! -
Jul 15 2014
Sean Congdon (B.S. University of Connecticut, 2013) joins the lab as our second Ph.D. student! -
Jun 15 2014
Josh gives an oral presentation titled "ProPeL: Using E. coli to Generate High Resolution Models of Protein Kinase Specificity" at the Phosphorylation & G-Protein Mediated Signaling Networks, Gordon Research Seminar in Biddeford, ME. [ link ] -
May 06 2014
The College of Liberal Arts and Sciences did a very nice story about Ragini and her future as a physician scientist (Ragini will be attending the Stanford MD/PhD program in the fall). [ link ] -
May 05 2014
Ragini is selected among all of her graduating peers in biology for the "Excellence in Applied Genetics and Technology Award". Congrats Ragini! -
May 03 2014
Matt, Kevin, and Ragini receive medals at the honors medal ceremony. [ file ] -
May 02 2014
First Schwartz Lab dinner held at Willington Pizza! [ file ] -
Apr 24 2014
Jesse is awarded a UConn IDEA grant for the development of "Curating Unified Publications" (CUP). Congrats Jesse! [ file ] -
Feb 14 2014
Will Percival (CSE '15) and Jessie Ostrander (CSE '16) both start working as programmers on the dry side of the lab. Welcome Will and Jessie! -
Jan 21 2014
Jesse Wang (PNB '15) officially starts working on a self-designed project in the dry lab as an honors student researcher. Welcome Jesse! -
Dec 17 2013
Julie is selected to become a 2014 University Scholar. Congratulations Julie! -
Oct 09 2013
News story about the pLogo tool posted on UConn Today. [ link ] -
Oct 06 2013
New publication: "pLogo: a probabilistic approach to visualizing sequence motifs". [ link ] -
Sep 27 2013
See a brief flash of our lab at around the 17 sec mark in the new UConn Public Service Announcement "Unleash Your Potential". [ link ] -
Aug 22 2013
pLogo web site live! [ link ] -
Jul 21 2013
New publication: "DYX1C1 is required for axonemal dynein assembly and ciliary motility." [ link ] -
Jul 11 2013
New web site launched: peptidextender is an interactive web utility for creating aligned PTM data sets from MS/MS tryptic peptide output. The utility can be found on the "webtools" page. This is an early release so please report any bugs. -
Jun 11 2013
Julie Klaric officially starts working in the experimental side of the lab. Welcome Julie! -
May 17 2013
Proceedings of the 2013 International Symposium on Bioinformatics Research and Applications (ISBRA) published by Springer. [ link | link ] -
Apr 25 2013
New web site launched: webroc is an interactive web utility for plotting receiver operating characteristic (ROC) curves. The tool can be found on the "webtools" page. This is a beta release, so please let us know if you find any bugs. -
Apr 23 2013
Josh and Dan present posters at Experimental Biology 2013 in Boston, MA. [ link ] -
Apr 04 2013
University of Connecticut 2013 Symposium on Digital Media / Innovative Collaborations. Dan presents at (and moderates) the Science, Technology, Engineering, and Mathematics (STEM) afternoon breakout session. [ link | link ] -
Apr 01 2013
Honors student Julie Klaric (Biological Sciences '15) was awarded a SURF Grant to do research in the Schwartz Lab over the summer. Congrats Julie! We're looking forward to having you in the lab. -
Mar 29 2013
Ragini receives the 2013 Goldwater Scholarship. She becomes one of only 271 student across the country awarded the scholarship in 2013, and one of only four students in the state of Connecticut. Be sure to congratulate her on this impressive achievement! [ link | link ] -
Mar 14 2013
New lab web site launched! It's probably going to be a bit buggy for a while, so bear with us (and let us know if you find a bug). -
Mar 13 2013
Congrats to Ragini, Kevin, and Matt for being named 2012 New England Scholars (>3.7 GPA for each of the Fall and Spring 2012 semesters). [ link ] -
Mar 12 2013
Various lab members are awarded scholarships from the School of Engineering. Joey is awarded the SCRRRA Green Energy Scholarship and the Arthur F. Munter, Jr. Memorial Scholarship; Ragini is awarded the Northeast Utilities Engineering Scholarship; and Kevin is awarded the Harold P. Farrington Engineering Scholarship. Congrats to Joey, Ragini, and Kevin. -
Dec 26 2012
New publication: "Using bacteria to determine protein kinase specificity and predict target substrates." [ link ] -
Dec 18 2012
Dan is serving as a program committee chair for ISBRA 2013 to be held in Charlotte, NC this May. Please see the CFP and associated deadlines. [ link ] [ file ] -
Nov 30 2012
New publication: "Transphosphorylation of E. coli proteins during production of recombinant protein kinases provides a robust system to characterize kinase specificity." [ link ] -
Oct 26 2012
Dan presents at the Plant Phosphorylation Workshop in Keystone, CO. -
Oct 09 2012
Jordan Force (EE '16) joins the lab as a programmer. Welcome Jordan! -
Aug 27 2012
Matthew Morris (PNB '14) and Jerlon Chiu (Biological Sciences '15) start the semester as honors student researchers on the experimental side of the lab. Welcome Matthew and Jerlon! -
May 29 2012
Ted Heying (Simpson College, Biology '13) joins the lab as a summer REU research student. Welcome Ted! [ link ] -
May 25 2012
Dan authors a book chapter on the prediction of lysine post-translational modifications. [ link ] -
Apr 13 2012
David presents his honors thesis research at the 2012 Frontiers Undergraduate Research Poster Exhibition. [ file ] -
Apr 05 2012
Ragini receives an honorable mention in the 2012 Barry M. Goldwater Scholarship. Congrats Ragini! [ link ] -
Feb 01 2012
Kevin Ryan (CSE '14) and Joey O'Shea (CSE '14) join the lab as programmers. Welcome Kevin and Joey! -
Dec 16 2011
scan-x included in latest issue of Current Protocols in Bioinformatics. [ link | link ] -
Nov 01 2011
Ragini Phansalkar (MCB & CSE '14) joins the lab as an honors student researcher. Welcome Ragini! -
Oct 28 2011
David Lindsay (PNB '12) joins the lab as an honors student researcher. Welcome David! -
Oct 10 2011
Honors Core: Computational Molecular Biology is now cross-listed as PNB 1401. Interested students should register for next semester. -
Sep 07 2011
motif-x included in latest issue of Current Protocols in Bioinformatics. [ link | link ] -
Aug 31 2011
Dan is co-instructing Honors Core: Computational Molecular Biology (BME/CSE/MCB 1401) this semester. [ link ] -
Aug 12 2011
Invited talk at the Workshop on Genomics and Proteomics of Oncogenic Viruses - Syria, VA. [ link ] -
Jun 10 2011
Mai Hamdalla begins working in the lab as a programmer/Web developer. -
May 23 2011
Ahmet Mingir and Saad Quader begin positions as the lab's first programmers/Web developers. -
Apr 06 2011
Bioinformatics software developer position now available. See the "positions" page. -
Mar 23 2011
Josh Lubner (B.A. Cornell) will be joining the lab in Fall 2011 as the lab's first Ph.D. student! -
Mar 08 2011
Student Web programmer position available. Apply here. [ link ] -
Feb 03 2011
Invited talk at the 1st IEEE International Conference on Computational Advances in Bio and medical Sciences (ICCABS) - Orlando, FL. [ file ] -
Dec 03 2010
Podcast of research on CLAS web site. [ link ] -
Nov 15 2010
Lab openings available. See the positions page. -
Oct 08 2010
Dan will be teaching a 1-credit graduate PNB seminar (PNB 6400) in the Spring. Interested graduate students should register soon. [ file ] -
Sep 20 2010
BioTechniques write-up of the virPTM database. [ link ] -
Aug 23 2010
Dan starts a new position as an Assistant Professor in the Department of Physiology and Neurobiology at the University of Connecticut in Storrs, CT. [ link ]